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These changes are enhanced by modifications in key regions such as the insular cortex (main area for taste processing) and caudate nucleus, where GLP-1-RAs are capable of normalizing altered brain activation patterns in patients with obesity and diabetes mellitus when exposed to hedonic gustatory stimuli (173, 174)

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Exenatide (2 mg, once weekly) for 6 weeks was studied together with nicotine replacement therapy in prediabetic and/or overweight smoking subjects ( n = 84)